IlpoOHOTHKH, HX xapaKTepHCTUKa H npuMeHHeMLie ouonpenapaTLI

Cyt:QecTByeT TpH rpynrrbI KoppernpyJOIUHX MHKpoqinopy npenapa­ T0B - npo6HOTHKH, npe6HOnfKH n CHH6HOTHKH.

llpo6uomu1<.u (probiotic - opraHH3M, yqaCTByJOIUHH s CHM6Ho3e) -

)KHBbie MHKpoopraHH3Mbl, H0pMaJibHbie o6nTaTeJIH KHllle'l{HHKa 3.D.0p0BOro qeJIOBCl<a (rraKTo6aUHJIJibI, 6Hq>H.n:o6aKTepHH, 3lllepmum H.np.), Ha 0CH0Be K0TOpbIX C03.D.aHbI npenapaTbI - npo6HOTHKH. 3TH MHKpoopraHH3Mbl He mrroreHHbl, He TOKCHfeHHbl H.n:ocTaT0'l{HO ycT0H'l{HBbl npH xpaHeHHH.

Ilpo,ll,BHra.srcr:, no nHw.esapwrem,HoMY i-pal<l)', npo6HoTHKH coxpa.ID110T

)KH3Hecnoco6HocTb. OHM 06ecneqJ1sa10T speMeHHoe 6narorrpH.sITHoe B03-

,n:eiicTBHe Ha KHllle1JHMK - MO,UHq>HUHpylOT ero C0CTaB H MeTa6ormqecK)'10

AKTHBHOCTh.

OKa3bIBa.sr 03.n:oposn.si:101:Qee,neikTBHe Ha)KI(T H 0611a.n:ru1 HMMYH0- CTHMyrrHpyww.eif aKntBH0CThlO, npo6HOTHKH cnoco6CTByJOT yrryqllleHHJO 3.n;OpOBJ:,.sI 'l{eJIOBe Ka.

26

 

TTpenapaTbI npo6HOTHKOB no,n:pa3)].emnoT Ha MOHOKOMTIOHeHTHbie, co­

,JJ.ep)KaIIJHe MOHOKYJ1b1)'py O)].HOro BH)],a 6aKTepHH, H TIOJlHKOMllOHeHTHbie,

B COCTaB KOTOpbIX MOryT BXO.ll.lITb MHKpoopraHH3Mbl pa3JlH1-IHbIX BH)].0B J,fJlH HeCKOJlbKO IllTaMMOB O,[{Horo BH)].a, a TaIOKe BemecTBa, TIOBbIIllaIOIIJHe aKTHBHOCTb np enapaTa.

 

Eutj,U<)ocooepmaw,ue npenapamb1. Hx,neucrny10nmM Ha<1anoM SIB­ Jl.llIOTC.ll 6ttqm.uo6aKTepHH, o6na.uaromHe BhICOKOH aHTaroHHCTH'leCKOH aK­ THBHOCThlO nponrn rrrnpoKoro crreKTpa naToreHHhIX HycnoBHo-rraToreHHhIX 6aKTepHH. 3TH npenapaThl HOpManH3YIOT MHKpoqmopy KHilleqHHKa, ITOBhl­ IIIaJOT ero KOJTOHH3aU:HOHttyIO pe3HCTeHTHOCTh.

MOJlOKOMnoHeHlnHble npenapambl.

BHcj)H.n:yM6aKTepHH - co.n:ep)l(HT)l(HBhle JlHOq:>HJlbHO BhlcymeHHhle 6mpH.n:o6aKTepHH BHJJ.a B.bifidum, 11x KOHU:eHTpan:H.ll cocrnrurneT B O)],HOH,IJ,03e He Meuee 108)l(HBhIX 6aKTepHH.

TloilUKOMtlOHeHmHble, KOM6UHUpoeanHble u cop6upoeaHHble npenapambl: BmfmcpopM-co.n:ep)l(JIT 6ttqm.n:o6aKTepHH(B.bifidum) H3HTepoKOKKH (S. faecalis).

BmpHKOJl - co.uep)l(HT 611cj)HJJ.06a1<Tep1rn H 3IllepHXHH (B.bifidum, IllTaMM Escherichia coli M-17).

Bmptt.r1m (KoM6HHHpoBaHHhIM npenapaT) - co.n:ep)l(HT B.bifidum H J1H3OU:HM.

Em:pHJJ.YM6aKTepHH-cpoJ)Te H TTpo6mpop- co.uep)l(aT B.bifidum, a.n:cop- 611poBaHHbie Ha aKTHBHpOBaHHOM yrne (copfo1poBaHHbIH npenapaT).

<l>nopa.n:ocpttmoc - cMec1, nuoqnrnhHo BhicyweHHhIX B.bi fi dum, B.longum, L.acidophylis, L.bulgaricus H Streptococcus thermophylus (6HonornqecKH aKTHBHaSI.uo6aBKa K IlHIIJe - EA)]J

 

Da1<.mocooepmaw,ue npenapamb1. JJ:etrcTBYIOIIJee uaqano 3THX npenapaTOB -)l(HBbie naKT06au:HJ1m,1, 06J1a.ua10mHe IIIHpOKHM cneKTpOM aHTaroHHCTI,JtJeCKOH aKTHBHOCTH no OTHOilleHmo K naToreHHhIM J,f ycnOBHO­ naToreHHbIM 6aKTepH.llM 3a cqeT npOJJ.YKU:HH opraHWieCKMX KHCJlOT, nepe­ KHCH BOJlOpo.n:a H JlH3OU:HMa.

MoHOKOMnOHeHmHble npenapambl co.uep)l(aT)l<HBhie JlHO<pHJlhHO BhICYilleH­ Hhie naKT06au:mrn1,1pa3HhIX BH)].OB:

JlaKTo6aKTepHH- L.plantarum, bHo6aKToH - L.acidophilus. facTpo<papM - L.bulgaricus

Ilo.r1u1<0Mno11eHmHble npenapamb1:

27

 

A1.umaKT- co.nep)KHT nnoqm.11bHo BblcyrneHHbie:>KHBbie L.acidophilus

Tpex I.I.ITaMMOB.

nnHeKC - B C0CTaB npenapaTa BX0,[(.SIT)KHBble JIHOq>HJIH3HpOBaHHbie 6aKTepm.f an.nos L.acidiphilus, B.infanti s, S. faecalis.

Aunnon- co.nep)l(HT L.acidophilus Hrronncaxapn.n 1<eqmpHbIX rpn61<os

(HMMYHOCTHM)'JI.IITOp).

TipHMa,noqrnmoc - cMeCb)KHBblX JIHOq>HJibHO BblcyrneHHbIX L.acidophilus, L.rhamnosum, B.infantis, B.adolescentis Ha ocHose MaJibTO,[(eI<cTpHHa (EA). TipenapaT C0CTaBJieH C yqeT0M BH,nOBOro C0CTaBa 6Hqm.no- H JiaI<To6aunnn y mo,neH pa3JIH'IHblX B03paCTHbIX rpyrm.

Ko!lucooep:m:atl(Ue npenapambl (MOHOKOMflOHeHTHbie "IlOJlHKOMfl0- HeHTHbie) co.nep)KaT:>KHBbie JIHOq>HJTbHO BbicyrneHHble I.I.ITaMMbl KHllletJHOH nanoqKH - Escherichia coli, K HHM OTHOC.IITC.sl KonH6aKTepHH, EHq>HKOJT, Euoq>nop.

- KonH6aKTepHH - co,nep:>KHT 6aI<TepHH aHTaroHHCTHt.J:eCKHaKTHBH0ro IIITaMMa E.coli M-17. TiperrapaT Ha3Hat.JaIOT npH Bblpa)KeHHOM.neq>HUHTe E.coli. Konu6aKTepHH HOpMaJIH3yeT cl>H3Honornqec1<oe paBHOBec11e KH­ me,moH MHKpOq>JIOpbI, 803,[(eHCTBYSI Ha MHOrHe rraToreHHMe H ycJI0BH0- rraroreHHbie MHKpoopraHH3Mbl.

 

llpenapamb1, npuzomo6JleHHb1e u3 opyzux _6U006 6a1<.mepuu _UJlU

MUl<.J)OOHblX Mema60J1Umo6.

- Tipenapa-r1,1 Crropo6aKTep1rn,EaKTHcnopHH, EaKTHcy6THJI co,nep)KaT

)KHBble K}'Jibzyp1:,1 a3po6HbIX crroporeHHbIX rranot.JeK po,na Bacillus - B.cereus HJIH B.subt ili s. O6na.na.11 caxapoJIHTHt.JeCKHMH q>epMeHTaMH, 6aQHJIJibI o6- pa3YJOT KHCJTYIO cpe.ny, nperr.SITCTBy.s1 rrpoueccaM rn11emu1, cnoco6cTBYIOT CHHTe3y BHTaMHHOB rpynn1:,1 B H p B KHIIIet.JHHKe.

MHKpoopraHH3Mbl, COCTaB.JUIIOI.UJ.fe OCH0BY 3THX npenaparoB, He OTH0- C.IITCSI K xapaicrepm,IM rrpe,!lCTaBHTeJTSIMHOpMaJibHOH MHI<pocl>Jiop1:,1KHIIIe'IHHI<a. RxH3JIHIIJHee pa3MHO:>KeHHe Ha cpoHe CHIDKeHIDl KOJIH'leCTBa 0CHOBHblX npe.n­ CTaBHTeJieH o6mmrrao:i% MHKpoqmopbI MO>KeT 0TIIr0IIJJITb Tet.JeHHe,[(HC6aKTe­ pH03a, oco6eHHo y H0Bopm1<,nemn,rx H,nereii MJia,nmero B03pacrn. Tio3TOM)' rrpHMeHeHHe TaKHX rrperraparoB IlOI<a.3aHO TOJlbKO _,[(en(M CTapme 7 JleT. Qe­

necoo6pa3HOCTh Ha3Hat.Jemu1 nperraparos, co.nep:>KalllHX B.subtili s-B.cereus,

.no.JDKHa ouemmaT1:,c.11B KIDK,ll,OM KOHKpernoM cnyqae 3a6011esaHID1.

- XIDiaK-<pOpTe - He co.nep)KHT)KHBl:,IX 6 aKTepHM, s ero COCTaB BXO­

,[(.SIT TOJlbKO cy6cTpaThI rrpo,nyKTOB)KJi3He,!le.slTeJibH0CTH E.coli, S.faeca li s,

28

L.acidophilus, L.helveticus, a TaIOKe Ha6op coneii H MOJIOT.JHrur KHCJIOTa. IlpenapaT cnoco6cTByeT BOCCTaHOBJieHHIO HOpMaJibHOH MHKpoq,nopbI KHIIIeT.JmlKa, HOpMaJIH3YeT CHHTe3 BHTaMHHOB rpynnhI 8 H K, CTHMyJIH­

pyeT pereHepa[(lflO CJilf3lfCTOH o60JIOT.JKH KHIIIeT.JHHKa, BOCCTaHaBJIHBaeT KHCJIOTHOCTb H HapymeHHbIH BO.IJ:H0-3JieKTpOJIHTHT.JeCKHH 6anaHc B npo­

CBeTe KlfIIIKlf.

 

IlpenapaTbI-npo6HOTlfKlf, pa3pa6oTaHHbie Ha Kaq>e,z:i:pe MHKpo6Ho­ JIOrIUI PfMY.

I. Enq>n.nyM6aKTepHH attn 16n oTHKoycTonq lf BhIH.

2.)KJ]ECK (:>KHBOH neT.Je6HhIH cTpenToKOKK KHIIIeT.JHHKa), co,z:i:ep)l(HT

)l(HBbie JllfOq>lfJibHO BbICYIIIeHHbie 3HTepOKOKKH - S.fa ecali s, npe,z:i:Ha- 3HaT.JeH,[{JUI Koppe lflf MHKpOq>JIOpbI KHIII eT.JHHKa                                                   .

3.)IOIEM:HK ()l(eHCKHH rreqe6HbIH MHKpo6), co,z:i:ep)l(lfT)l(HBbie IIITaMMhI

L.fermentum, npe,nHa3HaT.JeH)J,ml KOppeK[(Hlf BarHHaJibHOH MHKpo­ q>nopbI.

 

Ilpe6HOTHKH H CHH6HOTHKH

Ilpe6uomu,<.u - npenapambl HeMu1<.po611020 npouexo;;,coe11UJ1., 11e ao ­ eop6upy10me.H. 6 6epx11ux omoeJlax nuU{,e6apume.nb11020 mpaKma, enoeo611bl emUMyllupo6amb poem WlU Mema6oJlU'leeK)'10 aKmU61I0emb 110pMGllb1IOU MUKpO<pllOpbl KUUle'lHUKa. l/aU{,e 6ee 2 0 6eU{,eem6a, eoema6JlJl10U{,Ue 0CH06Y np e6uomu Ka,.H.6JIJl10mC.H. HU3K0M0JleK)'JlJlpHblMU y2lle600a.MU (0llU20eaxapu­ Obl, <ppyKmOOJlU20eaxapuiJbl), eooep;;,camc.H.6 2 py iJHOM M0Jl0Ke U 6 HeKomo­ pblX nUU{,e6blX npoiJyKmax.

- JlaKTYJI03a (.D:IOq>arraK)- co,nep)l(JIT cHHTeTHT.JecKHH.nncaxapH,n. JlaK­ ryno3a rn.npomi3yeTC.il MHKpoq>rropon TOJICTOro KlfIIIeT.JHHKa B OCHOBHOM.no MOJIOT.JH OH' KH  CJIOTbI,  KOToprur CTHMyJIHpyeT n epH CTaJibTHKY, cnoco6cTByeT CHH)l(eHlflO p H, ceJieKTIIBHO HCTIOJih3yeTC.il 6ltq>H,no6aKTepHRMH H rraKT0- 6 aKTepHRMH, cnoco6cTBy.i1 HX pocry Hpa3MHO)l(emno.

- IlaHTOTeHaT KaJib[(H.il - YTHJilf3HpyeTC.il 6Hq>H,z:i:o6aKTepHRMlf, CTHMYJIHpyeT HX pocT H pa3MHO)l(eHHe, yT.JaCTByeT B nponeccax OKHC­ JieHH.il B KJieTKax.

 

Cu116uomu,<. u -   n p ena p am b z, npeoema6JlJl10U{,U e co6ou KoM6uHa'14uu npo6uomuKo6 u npe6uomuK06, oHu U36upamellb1IO emUMyllupy10m poem u Mema60Jtu'lee1<.y10 aKmU6Hoemb uHiJu 2 e1111ou MUKp O<pll Op bl, no6blUta10m

<paKmOpbl eemeem6eHHOU 3GU{,Umbl op 2 aHU3MG.

29

 

- EHoBecnmr-naKTo-co.nep)l(JIT 6mlm.noreHHbie cl>aKTOpbI H 6HoMaccy 6aKTepHH B.bifidum, B.adolescentis, L. plantarum.

6.ruoT06uonornH.IlpaKTnqecKoe3uaqeuue

I'Homo6mo11ozua - Hay1<.a (pa3oen 31<.cnepUMeHmaJlbHoii 6uo11ozuu U.MeOUU,UHbl), 3QHUMQIOU{llJlC.R no11y11enue,w U 6btpaU{U6QHUe.M:JICU60m­

HblX, c6o6oonw.-c om Mu«.poopzaHU3M06 (znomo6uonmoB) u U3y11enue.M

UX:JICU3HeOeRmeJLbHOCmU.

Ee3MHKpo6HbIX)KHBOTHblX, HanpHMep MbIIlleH, nonyqaIOT nyTeM acenTl-fqCCKOro BCKpbITH.sI MaTKH 6epeMCHHOH MhlllIH H H3BJ1eqeHml H3 Hee MbIUiaT, KOTOpbIX BblpaIUHBaIOT B CTepHJibHbIX ycnOBH.sIX B cne:uuam,HOM rHOT06HOJIOrHqecKOM H30JI.sITOp e, KOpM.sIT CTepHJibHOH 1mmeii, TIOCTO.sIHHO

npOBOJl.sIT KOHTpOJib Ha OTCYTCTBHe MHKpocpnopbI. BpeMCHHOe IlOJIHOe YJ{aJieHHe HOpMaJibHOH MHKpoct>nopbl KHilleqHHKa B03MO)KHO H y MbllllCH, BbipameHHbIX B 06b1qHbIX ycnOBIDIX, nyTeM BBe.neHH.sI HM KOMTJneKca aH­ TH6HOTHKOB (CM. MCTO.IlHKY rHOT06HonoruqecKoro 3KCn ep HMeHT a).

Ha)KHBOTHbIX-rHOT06HOHTax1nyqaIOT MexaHH3Mbl H cpopMbl B3aHMO­

.neHCTBIDI MHKpo6oB H MaKp oopr aHH3Ma. BbI.sICHCHO, 'ITO HOpMaJibHa.sI)KH3- He.neBTCJ1bHOCTb BbICillHX)KHBOTHbIX, B TOM qffcJie H qenoBeKa, B03MO:>KHa JIHillb rrpH coxpaHHOCTH B opraHH3Me ecTeCTBCHHOH MHKpocl>nopbI.

rttoT06HOJIOn1qecKHe 3KCrrepHMeHTbl rrp0Bo.n.s1T, rrpe)KJJ;e Bcero, B Me.nHUHHCKOH 1-1 BeTepHHapHOH MHKpo6HonorHH, HH<peK:UHOHHOH 1-1 He­

HH<peKUHOHHOH HMMYHOJIOrHH H rraronorHH, npH H3yqeHHH cl>H3HOJIOrHH IlHJ.UCBapeHH.sI, B p a.n1-10 6HO JIOrH H.

rttOT061mnorHB Haxo.nHT npaKTHqeCKOe rrpHMeHeHHe B KJIHHWICCKOH Me.nHUHHe, B '-laCTHOCTH B XHpypnu1, OHKOJIOrHH, ne.nHaTpHH, OHa TCCHO CBB3aHa C KOCMHqecKOH 6HOJIOrHeH H Me.nHUHHOH.

 

 

CxeMa rnoT0611onoruqecKoro 3KcnepHMenTa no no 6opy pannoHaJILHOH aHTH6HOTHKOTepaDHII

1. TomOJlbHaJl iJeKoHmaMuHa1,fuJt (BpeMeHHOe yHJ,lqTO)KCHHe Bceii MHKpoqmopbI))Keny.no'-IHO-KHllle'-IHOro TpaKTa)KJ.IBOTHblX.,nn.11:noro MbllllaM B Te'-leHHe 5,n:HeH rrepopanbHO (qepe3 poT) BBOJl.sIT aHTH6HOTHKH

urnpoKoro cneKTpa.neHCTBH.sI: aMHKa:UHH (10 Mr/Mn)+ aMITHOKC (4 Mr/Mn)

+ HHCTanm (4 Mr/Mn).)l(HBOTHblM.naIOT CTepHJibHbIH KOpM H BO.ny, MOIOT B l% pacTBope xnopreKcH.nHHa.nn.11 CTepHJIH3aUHH KO)KHbIX IIOKpOBOB H

 

30

 

rrepeB0,LVIT B rHOT06HOJIOrJ,ftJeCKHM H30JHIT0p, rAe BB0,WIT aHni6HOTHKH

ern;e 0AHH cyTKH.

2. AoanmalJUH:JICUB0mHblX u rf>opMupoea11ue 1108020 MUKp06UOlJe­ H03a. OTMemIIOT aHTH6HOTHKH H BbIAep)KHBaIOT)KHB0THbIX B H30m1Tope 2 cyT0K, AeJialOT KOHTpOJihHbIH BhICeB cpeKaJIHH - MHKpocpnopa JJ:0JI)l(Ha 0TCYTCTB0BaTb. MHTparacTpaJibHO BB0AjJT)l(HB0THhlM 0,3 r.ri:eKaHTaTa cpeKaJIHH 60,'lhHoro mm paHeBoro 0TAengeMoro. Y MbillleM cpopMHpyercg

MHKpoq>Jiopa' KHlll  etJHHKa     ,  T0 ecTBeHHajJ MHKpocpnope  6oJibHOro.

3. H3yl/e11ue l/yecmeume'1b1Wcmu MUKporpllopbz K a11mu6uomuKGM in vivo. Mb1IIIaM lIHTparaCTpaJibH0 BB0,L{ITT pa3JIWIHbie a.HTI16HCYI"HI<H H BbUIBIDIIOT HaH6011ee aKrnBHbie rryTeM BbICeBa MHKpO<pJIOpbl Ha 3JieKTMBHbie IlHTme.Jil,Hble

cpeAbI. Ilocne aHaJIH3a nonyqeHHbIX pe3yJihTaTOB coCTaBJI.SllOT cxeMY Pa!OfO­

HaJihHOM airrn:6HOTHI<OTepamrn,wui K0ppeKQHH Mm<poqmopbl 6oJibHOro.

3TOT MeT0A peKoMeH.l{yeTCH npHMeHjJTb AJI.11 6onee 3cpcpeKTHBHOM aHn16HOTHKOTepanm1 60JihHbIX (He no;ma10rn;HMHC.II o6bitJHbIM MeT0JJ:aM JietJeHH.11), B TOM tJHCJie.l{JijJ rreqemrn MHTeJibH0 Teeyrn;HX, xpoHHtJeCKHX rHOHHO-BOCilaJIHTeJibHhIX 3a6 on eaaHHH.

 

KouTpom.ui.1e eonpoci.1 no TeMe 1auHTHH

1. 3KOJIOrHtJeCKa'1 MHKpo6HOJIOrHH (MHKp03KOJIOrH.11); ynoTpe6rureMble Il0IDITHH: 6HOTOil, MHKpo6HOUeH03, nonyrru].H.11, 3K0CHCTeMa.

2. IlepetJHCJIHTb Fl oxapaKTepID0BaTb THITbl Me)l(BHJJ:0BhIX B3aHM00TH0Uie­

HHH B 3K0CHCTeMe Me)l(.l{y nonyJI.sJUH.IIMH MHKpoopraHH3M0B B C0CTaBe 6HOUeH03a - HeHTpaJIH3M, CHM6H03, K0MMeHCaJIH3M, aHTar0HH3M,

napa3HTH3M.

3. Tio,n;pa3,n;eJJeHHe MHKpoqmopbl tJeJioBeKa B 38BHCHM0CTH OT ee Il0CT0- jJHCTBa H cpaKTOpbI, K0HTp0JIHpyiorn;He ee Il0CT0.IIHCTB0 a 6HOTOrrax.

4. 3Hat.JeHHe H0pMaJJI,HOH MHKpOq>JIOpbI JJ:JijJ opraHH3Ma qeJI0BeKa Fl

pa3BHTH.sl ero HMMYHHOH CHCTeMbl.

5. <l>yHKI.Um HOpMaJihHOH MHKpocpnopbI.

6. PoJib HOpMaJihHOH MHKpocpnopbI B o6ecneqemm KOJJOHH3aUHOHHOH pe3HCTeHTH0CTH K 3K30reHHbIM B036y,n;HTeJI.sIM, ee MexaHH3Mhl.

7. Ka11ecTBeHHhIH H KOJIHtJeCTBeHHhIH C0CTaB MHKpOq}JIOpbI pa3HbIX 06-

nacTeH (6HOTonoB) Tena 11enoBeKa - J<O)l(H, pecrrHpaTopnoro H yporeHH­

TaJihHoro TpaKT0B. Ponh HOpMaJibHOH MHKpoqmopbI 3THX 6HOTOITOB.

8. MHKpoq)Jlopa ITHrn;eBapHTeJibH0ro Tp aKTa. Ka11ecTBeHHhIH Fl KOJIH'le­ CTBeHHhlH C0CTaB MHKpocpnopbI poTOBOH Il0JJ0CTH,)l(eJiy.l{Ka, T0HK0ro

H T0JICT0ro KHIII e'I HHKa. IloJIOCTHaH H MYK03HaH MHKp o q>n o p a.

31

 

9. TiepeqHCJllITb H oxapaI<Teptt30BaTb OCHOBHblX npe.ucTaBJ.nenew HOp­ MaJlbHOH MHKpocpnopbI TOJICTOro KHilleqHHKa.

10..[.(1rnaMHKa p83BHTmI MHKpo6HoQeH03a TOJICTOro KHmeqHnKa y rpy.u­ HOro pe6eHKa. Bo3MO)l(HOCTb KOppeKQHH.uaHHOro npoQecca.

11. TioH.IITHe «.n;Hc6aKTepH03». 3Haqem1e,UHC6HOTHqecKHX H3MeHeHHH

HOpManbHOH MHKpoqmopbl H, oco6eHHO, MHKpocpnopbl TOJlCTOro KH­ weqHHKa.un.11 opraHHJMa.

12. <l>aKTOpbI, IIpHBOJl.llW:He K pa3BHTHIO,[{HC6aI<TepH03a.

13. CTa,n:HH (cTeIIeHH),UHc6aI<TepH03a, HX xapaKTepHCTHKa.

14. MeTOJlbl na6opaTopHoH.UHarHOCTHKH.UHc6aI<TepHo3a. EaI<TepHono­ rnqecKHH (KOJIHqecTBeHHbIH) MeTO.U HCCJie,[{OBamrn HCIIpa)l(HeHHH C

QeJiblO BblSIBJieHH.11,UHC6aKTepH03a.

15. MeTO,Ubl 3KCIIpecc-,n:HarHOCTHKH m-rc6aKTepH03a, Ha '-leM OCHOBaHbl, IIpHMepbI, 3HaqeHHe.

16. IlpHHQHIIbl KoppeKJ..lHH MHKpocpnopbI TOJICTOro KHWeqHHKa npH,[{HC-

6aKTepH03e.

17. Ilpo6HOTHKH, IIpHMeIDieMbie,UJI.11 KOppeKQHH,[{HC6aKTepH03a KHmeq­ IDIKa, HX xapaKTepHCTHKa. IlpHMepbl 6nonpenapaTOB npo6HOTHKOB p83JIHqHbIX THIIOB.

18. Ilpe6HOTHKH n CHH6HOTHKH, HX xapaKTepHCTHKa, IIpHMepbI 6Honpe­

napaTOB.

19. rHoT06HOJIOrH.11 H..e. e  npaKTHqecKoe  IIpHMeHeHHe  B 6HOJIOrHH  H  Me-

.lUill.HHe.

20.)KHBOTHble-n-IOT06HOHTbl, cnoco6bl HXnonyqeHIDI H co,n:ep)l(aHIDI.

21. CxeMa rHOT06YfOJIOrnqecKOro 3KCIIepHMeHTa C uem,IO OITTHMaJibHOro Il0)],6opa aHTH6HOTHKOB)].JI.II JieqeHH51 6oJibHOro.

 

32

 

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AHHTHe 11

IIJiau JaHHTHH:

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3. <l>aKTOpbl rraToreHHOCTH MHKpoopraHH3MOB: q:>aKTOpbI a.ure3HH H

KOJIOHH3aU:m i, HHBa3HH H arpeCCHH, 3HTHcparOUHTapHble cpaKTOpbI. IlpHMepbI H MexaHH3Mbl.ueikTBml.

4. baKTepHaJibHbie TOKCHHbl, rro,np a3,nene1rne. Knaccmpm<aUIDI 6eJIKOBbIX

TOKCHHOB no MexaHH3MY.neHCTBIDI. XapaKTepHCTHKarpynn TOKCHHOB. 3H,UOTOKCHHbl.

5. <I>opMbl HH<peKUHOHHb!X 6one3HeH. 3JieMeHTbl:mH,UeMHOJIOfHH.

6. JKCnepHMeHTaJibHa..sI HHcpeKUHH. UerrH H MeTO)]J,I 3apIDKeHHH 3Kcne­ pHMeHTaJibHbIX)KHBOTHbI X.

7. CaMOCTO.sITeJihHa.sI rrpa.KTH'{eCKa.11 pa6oTa - yqeT OilbITOB no Bbl.sIBJie­ HHIO cpaKTopoB naToreHHOCTH 6aKTepHH:

a) BnI.sIBJieHHe KarrcyJihI y KarrcyJibHbIX 6aKTepHH B OKpaweHHblX Ma3Kax KJie6cHenn H 6au:1mn H Kop.n-cpaKrnpa y Mycobacterium tuberculusis B Ma3Kax, OKpaweHHblX no I.l;HJJIO-HHnbcetty.

6) Tecn1HaITJia3MOKoaryna3y, r11anypoHH.Ua3Y, neU:HTHHa3Y,.[{HK­

a3y H reMOJIH3HHbl y CTa<pHJIOKOKKOB.