Вакцины на основе биотехнологий

Имеющиеся вакцины и их преимущества

 

В настоящее время рекомбинантные вакцины против каприпоксвируса на рынке отсутствуют. Однако разрабатывается новое поколение противокаприпоксвирусных вакцин, в которых геном каприпоксвируса используется в качестве вектора для генов других патогенов жвачных животных, таких как вирус чумы мелких жвачных (PPR) (Berhe et al., 2003; Tuppurainen et al., 2014).

 

3.2. Особые требования к биотехнологическим вакцинам, при наличии

 

Не применяются.

 

СПРАВОЧНАЯ ЛИТЕРАТУРА

 

BALINSKY C.A, DELHON G, SMOLIGA G, PRARAT M, FRENCH R.A, GEARY S.J, ROCK D.L & RODRIGUEZ L.L. (2008). Rapid preclinical detection of sheep pox virus by a real-time PCR assay. J. Clin. Microbiol., 46, 438–442. 

BERHE G., MINET C., LE GOFF C., BARRETT T., NGANGNOU A., GRILLET C., LIBEAU G., FLEMING M., BLACK D.N. & DIALLO A. (2003). Development of a dual recombinant vaccine to protect small ruminants against peste-des-petits-ruminants virus and capripoxvirus infections. J. Virol., 77, 1571–1577. 

BOWDEN T.R, BABIUK S.L, PARKYN G.R., COPPS J.S. & BOYLE D.B. (2008). Capripox virus tissue tropism and shedding: A quantitative study in experimentally infected sheep and goats. Virology, 371, 380–393. 

CAPSTICK P.B. (1961). Annual Report. Kenya Veterinary Department, Kenya, 45–47. 

CHAND P., KITCHING R.P. & BLACK D.N. (1994). Western blot analysis of virus-specific antibody responses to capripoxvirus and contagious pustular dermatitis infections in sheep. Epidemiol. Infect., 113, 377–385. 

DAS A., BABIUK S. & MCINTOSH M.T. (2012). Development of a loop-mediated isothermal amplification assay for rapid detection of capripoxviruses. J. Clin. Microbiol., 50, 1613–1620. 

DAVIES F.G. & MBUGWA G. (1985). The alterations in pathogenicity and immunogenicity of a Kenya sheep and goat pox virus on serial passage in bovine foetal muscle cell cultures. J. Comp. Pathol., 95, 565–576. 

DAVIES F.G. & OTEMA C. (1978). The antibody response in sheep infected with a Kenyan sheep and goat pox virus. J. Comp. Pathol., 88, 205–210. 

GELAYE E., LAMIEN C.E., SILBER R., TUPPURAINEN E.S., GRABHERR R. & DIALLO A.(2013). Development of a cost-effective method for capripoxvirus genotyping using snapback primer and dsDNA intercalating dye. PLoS One, 8 (10): e75971. 

HEINE H.G., STEVENS M.P., FOORD A.J. & BOYLE D.B. (1999). A capripoxvirus detection PCR and antibody ELISA based on the major antigen P32, the homolog of the vaccinia virus H3L gene. J. Immunol. Methods, 227, 187–196. 

IRELAND D.C. & BINEPAL Y.S. (1998). Improved detection of capripoxvirus in biopsy samples by PCR. J. Virol. Methods, 74, 1–7. 

KITCHING R.P., HAMMOND J.M. & TAYLOR W.P. (1986). A single vaccine for the control of capripox infection in sheep and goats. Res. Vet. Sci., 42, 53–60. 

KITCHING R.P. & SMALE C. (1986). Comparison of the external dimensions of capripoxvirus isolates. Res. Vet. Sci., 41, 425–427. 

KITCHING R.P. & TAYLOR W.P. (1985). Clinical and antigenic relationship between isolates of sheep and goat pox viruses. Trop. Anim. Health Prod., 17, 64–74. 

LAMIEN C.E., LELENTA M., GOGER W., SILBER R., TUPPURAINEN E., MATIJEVIC M., LUCKINS A.G. & DIALLO A. (2011). Real time PCR method for simultaneous detection, quantitation and differentiation of capripoxviruses. J. Virol. Methods, 171, 134–140. 

LE GOFF C., LAMIEN C.E., FAKHFAFH E., CHADEYRAS A., ABU-ADULUGBAD E., LIBEAU G., TUPPURAINEN E., WALLACE D., ADAM T., SILBER R., GULYAZ V., MADANI H., CAUFOUR P., HAMAMMI S., DIALLO A. & ALBINA E. (2009). Capripoxvirus G-protein-coupled chemokine receptor, a host-range gene suitable for virus-animal origin discrimination. J. Gen. Virol., 90, 67–77. 

MURRAY L., EDWARDS L., TUPPURAINEN E.S., BACHANEK-BANKOWSKA K., OURA C.A., MIOULET V. & KING D.P. (2013). Detection of capripoxvirus DNA using a novel loop-mediated isothermal amplification assay. BMC Vet. Res., 9, 90. 

OMOGA D.C.A., MACHARIA M., MAGIRI E., KINYUA J., KASIITI J. & HOLTON T. (2016) Molecular based detection, validation of a LAMP assay and phylogenetic analysis of capripoxvirus in Kenya. J. Adv. Biol. Biotech., 7, 1–12. 

STUBBS S., OURA C.A., HENSTOCKA M., BOWDEN T.R., KING D.P. & TUPPURAINEN E.S. (2012). Validation of a high-throughput real-time polymerase chain reaction assay for the detection of capripoxviral DNA. J. Virol. Methods, 179, 419–422. 

TUPPURAINEN E.S.M., PEARSON C.R., BACHANEK-BANKOWSKA K., KNOWLES N.J., AMAREEN S., FROST L., HENSTOCK M.R., LAMIEN C.E., DIALLO A. & MERTENS P.P.C. (2014). Characterization of sheep pox virus vaccine for cattle against lumpy skin disease virus. Antiviral Res., 109, 1–6. 

ZHAO Z., FAN B., WU G., YAN X., LI Y., ZHOU X., YUE H., DAI X., ZHU H., TIAN B., LI J. & ZHANG Q. (2014) Development of loop-mediated isothermal amplification assay for specific and rapid detection of differential goat Pox virus and Sheep Pox virus. BMC Microbiol., 14, 1–10. 

ZRO K., AZELMAT S., BENDOURO Y., KUHN J.H., EL FAHIME E. & ENNAJI M.M. (2014a). PCR-based assay to detect sheeppox virus in ocular, nasal, and rectal swabs from infected Moroccan sheep. J. Virol. Methods, 204, 38–43. 

ZRO K., ZAKHAM F., MELLOUL M., EL FAHIME E. & MUSTAPHA M. (2014b). A sheeppox outbreak in Morocco: isolation and identification of virus responsible for the new clinical form of disease. BMC Vet Res., 10, 31. 

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NB: Существуют Референтные лаборатории МЭБ по оспе овец и оспе коз (смотри таблицу в Части 4 данного Руководства по наземным животным или обратитесь к веб-сайту МЭБ за самым последним списком: http://www.oie.int/en/our-scientific-expertise/reference-laboratories/list-of-laboratories/). Для получения дальнейшей информации по диагностическим тестам и реактивам в отношении оспы овец и оспы коз следует обращаться в Референтные лаборатории МЭБ.