Image S5: ovalocytes and elliptocytes

Image S1: acanthocytes

Abetalipoproteinaemia - typical hyperchromic cells with projections of variable length, thickness and shape

 

J. Burthem, M. Brereton

 

 

Image S2: bite cells

 

Three bite cells

 

J. Burthem, M. Brereton

 

 

Image S3: blister cells

 

G6PD deficiency (drug induced haemolysis) - frequent blister cells with associated damaged cells

 

J. Burthem, M. Brereton

 

 

Image S4: echinocytes

Renal failure – cells with evenly spaced, short, blunt projections

 

J. Burthem, M. Brereton

2

 

Supplementary images: ICSH Recommendations for Peripheral Blood Cell Morphology

 

Standardization and Grading

 

Image S5: ovalocytes and elliptocytes

Hereditary elliptocytosis

 

J. Burthem, M. Brereton

 

 

Image S6: irregularly contracted cells

 

Unstable haemoglobin

 

J. Burthem, M. Brereton

 

Image S7: schistocytes

Thrombotic thrombocytopenic purpura – a wide range of fragmented red cells with polychromatic cells and other damaged cells. Platelets are absent from the film

 

J. Burthem, M. Brereton

 

Image S8: sickle cells

 

Sickle cell disease – typical forms together with other features, notably polychromasia, target cells, and a spherocytic cell.

 

J. Burthem, M. Brereton

3

 

Supplementary images: ICSH Recommendations for Peripheral Blood Cell Morphology

 

Standardization and Grading

 

 

Image S9: spherocytes

 

Autoimmune haemolytic anaemia – typical round, dense red cells

 

J. Burthem, M. Brereton

 

 

Image S10: stomatocytes

 

Hereditary stomatocytosis

 

J. Burthem, M. Brereton

 

 

Image S11: target cells

 

Haemoglobin C disease – target cells in association with irregularly contracted cells

 

J. Burthem, M. Brereton

 

Image S12: tear drop cells

 

Myelofibrosis

 

J. Burthem, M. Brereton

4

 

Supplementary images: ICSH Recommendations for Peripheral Blood Cell Morphology

 

Standardization and Grading

 

Image S13: basophilic stippling

 

Myelofibrosis - two stippled cells, one in teardrop form

 

J. Burthem, M. Brereton

 

Image S14: Howell-Jolly bodies

Auto-splenectomised patient with sickle cell disease

 

J. Burthem, M. Brereton

 

 

Image S15: Pappenheimer bodies

 

Sideroblastic anaemia – red cells contain small basophilic inclusions of variable size and shape in a limited cytoplasmic area

 

G. Rozenberg

 

(Copyright: Microscopic haematology: a practical guide for the laboratory 3e (c) 2011, Sydney, Elsevier Australia)

 

 

Image S16: nucleated red blood cell

 

Myelofibrosis – a typical late stage nucleated red cell in circulation

 

J. Burthem, M. Brereton

5

 

Supplementary images: ICSH Recommendations for Peripheral Blood Cell Morphology

 

Standardization and Grading

 

 

Image S18: Auer rods

 

AML – two blast cells containing relatively blunt-ended, single and multiple Auer rods

 

J. Burthem, M. Brereton

 

Image S19: hypergranulation

(neutrophils)

 

Hypergranular neutrophils post G-CSF treatment

 

J. Burthem, M. Brereton

 

 

Image S20: hypogranulation

 

(neutrophils)

 

Myelodysplasia – hypogranular neutrophils.

 

Note also the atypical nuclear forms

 

G. Rozenberg

 

(Copyright: Microscopic haematology: a practical guide for the laboratory 3e (c) 2011, Sydney, Elsevier Australia)

6

 

Supplementary images: ICSH Recommendations for Peripheral Blood Cell Morphology

 

Standardization and Grading

 

 

Image S25: monoblasts

 

Acute monoblastic leukaemia – monoblasts and promonocytes

 

J. Burthem, M. Brereton

 

Image S28: hairy cells

 

Hairy cell leukaemia

 

J. Burthem, M. Brereton

8

 

Supplementary images: ICSH Recommendations for Peripheral Blood Cell Morphology

 

Standardization and Grading

 

 

Image S30: plasma cells

 

Plasma cell leukaemia. Note also the background protein staining and the associated red cell rouleaux. Note that one plasma cell has features of immaturity and may be regarded as a plasmablast.

 

J. Burthem, M. Brereton

 

 

Image S33: giant platelets

 

Myelofibrosis – some large and giant abnormally granulated platelets and a micromegakaryocyte

 

J. Burthem, M. Brereton

 

Image S1: acanthocytes

Abetalipoproteinaemia - typical hyperchromic cells with projections of variable length, thickness and shape

 

J. Burthem, M. Brereton

 

 

Image S2: bite cells

 

Three bite cells

 

J. Burthem, M. Brereton

 

 

Image S3: blister cells

 

G6PD deficiency (drug induced haemolysis) - frequent blister cells with associated damaged cells

 

J. Burthem, M. Brereton

 

 

Image S4: echinocytes

Renal failure – cells with evenly spaced, short, blunt projections

 

J. Burthem, M. Brereton

2

 

Supplementary images: ICSH Recommendations for Peripheral Blood Cell Morphology

 

Standardization and Grading

 

Image S5: ovalocytes and elliptocytes

Hereditary elliptocytosis

 

J. Burthem, M. Brereton